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Your Trusted Advisor for Assessing the Endocrine-Disrupting Potential of Chemicals

Endocrine disruption from chemical exposure occurs when endocrine-disrupting chemicals (EDCs) interfere with the natural hormone systems in humans or other non-human living beings. Even subtle disturbances to these finely regulated systems can potentially lead to adverse effects, e.g., on reproduction, growth, and development. EDCs may be ubiquitously present in a wide range of sources, such as everyday consumer products, food-contact materials, or industrial materials. As the regulatory landscape for endocrine disruption continues to evolve, DHI can help you understand, navigate, and comply with emerging regulatory requirements.

 

At DHI, we deliver independent, science-driven assessments of potential endocrine disruption using state-of-the-art tools and strategies tailored to your needs.

Key services

  • Comprehensive review of existing regulatory data
  • Targeted literature searches for mechanistic and regulatory evidence
  • QSAR-based in silico screening for endocrine-related endpoints
  • Tailored testing strategies integrating in vitro and in vivo studies
  • Monitoring and supervising ED-specific studies and coordination with CROs
  • Read-across justification compliant with regulatory-recognized guidelines
  • Strategic advice for submissions and representation at authorities

Value-added expertise

  • ECHA/EFSA-compliant assessment of lines of evidence for endocrine disruption
  • Integration of multiple lines of evidence for weight-of-evidence (WoE) conclusions
  • Generation of Robust study summaries
  • Preparation of regulatory dossiers, position papers, scientific reports, and addressing the relevance of ED potential for human health and the environment

Regulatory expertise

  • CLP classification including new ED hazard classes
  • IUCLID dossier preparation for REACH, BPR, PPP
  • OECD 150 compliant EDSP data generation (Levels 1-5)
  • Representation at ECHA RAC, BPR WQ and other regulatory meetings
  • CRO selection and GLP study oversight

Scientific areas covered

  • Industrial Chemicals (REACH, CLP)
  • Biocides (BPR)
  • Plant Protection Products (PPP)
  • Medical Devices (MDR, ISO 10993)
  • Pharmaceuticals (ICH M7)
  • Packaging & Food Contact Materials